The Qualitative Determination by RP-HPLC and Polagraphic Determination of Ralidaine in Pharmaceutical Dosage Form

The Qualitative Determination by RP-HPLC and Polagraphic Determination of Ralidaine in Pharmaceutical Dosage Form

Zajel / An-Najah National University

Hind Hasna A simple, accurate and rapid method for the quantitative determination of five ranitidine drugs in pharmaceutical formulations (Tablets and Ampoules) is proposed. The supporting electrolyte was acetic acid - sodium acetate buffer solution (pH 5.2). An excellent linear relationship was obtained between the concentration and current with correlation coefficient 0.9996. Good agreement was obtained between the results with the d.c. polarographic method and those by the manufacturer’s method of assay. Hind Hasna Supervisor Dr. Ali Z. Abu-Zuhri 1989