| Alaeddin Omar Abu-Zant
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Methicillin-resistant Staphylococcus aureus (MRSA) prevalence has been reported worldwide, but not well surveyed in Palestine. A total of 401 isolates of S. aureus was 11%. The resistance rates of MRSA to other antibiotics were as follows: 22.7% resistant to ciprofloxacin, 50% clindamycin, 84.1% to erythromycin, 59.1% to gentamicin and only 2.3% to co-trimoxazole. No resistance to vancomycin was detected. 38.6% of the isolates were noted to be multiple resistant, i.e., resistant to erythromycin and two or more of the following antibiotics: gentamicin, ciprofloxacin and clindamycin.
Quantitative antubiogram and AP-PCA were evaluated for their performance and convenience to define clones and to discriminate between epidemic and sporadic MRSA. AP-PCR identified 20 types among the 43 examined isolates and only one of the epidemiolgically unrelated isolates was missclassified, while, quantitative antibiogram enable the detection of 15 patterns among the same isolates. On the other hand, it failed to exclude 5 of the unrelated isolates from the clusters. AP-PCR identified all the 23 epidemic associated isolates as a single epidemiological clone, 18 of them were further divided into 4 subclones using antibiogram. The remaining isolates were sporadic, caused by MRSA, however, combination of both methods seems to have a greater value in epidemiological investigation.
Alaeddin Omar Abu-Zant
Supervisors
Dr. Kamel Adwan
Dr. Nael Abu-Hasan
Dr. Moien Kanaan
1999
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